HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Difluorobenzene → (3,4-Difluorophenyl)(piperidin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Difluorobenzene | HCID 9706 | — |
| Reactant | 1-Acetylpiperidine-4-carbonyl chloride | HCID 100950 | — |
| Reactant | 1-Acetyl-4-(4-fluorobenzoyl)piperidine | HCID 117257 | — |
| Product | (3,4-Difluorophenyl)(piperidin-4-yl)methanone | HCID 14674155 | — |
| Product | HCID 19771920 | HCID 19771920 | — |
Reaction Steps
Following the procedure for the preparation of 1-acetyl-4(4-fluorobenzoyl)piperidine (U.S. Pat. No. 3,576,810), 1-acetyl-4(3,4-difluorobenzoyl)piperidine is prepared from 1-acetylisonipecotic acid chloride and 1,2-difluorobenzene. The acetyl group is removed by hydrolysis in dilute hydrochloric acid. Basification followed by extraction with a suitable solvent yields the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05198449 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-155d9c1cc1e144ee8ae9517ed1295278 |
| Source note | uspto-grants-1993_03 |