Methyl Isocyanate → HCID 19772030, compound

Participants

Reaction Steps

A solution of 2.25 g (0.0072 mol) of α-(4-fluorophenyl)-N-(2-phenylethyl)-4-piperidinemethanamine and 2.50 g (0.044 mol) of methyl isocyanate in 200 mL of methylene chloride was stirred at room temperature overnight. The solvent was removed in vacuo to give a solid. This was triturated with anhydrous ether, and the solid was collected to give 2.43 g (79.1%) of white solid, mp 186°-188° C.

Provenance & Evidence