6-(2-amino-5-bromopyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one → 6'-amino-N-(cyclopropylmethyl)-N-methyl-5'-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-[2,3'-bipyridine]-5-sulfonamide

HRID 161465Notes

Reaction equation

HRID 161465 reaction equation
[CH:1]1([CH2:4][N:5]([S:6](=[O:7])(=[O:8])[c:9]2[cH:10][n:11][c:12]([Sn:15]([CH3:16])([CH3:17])[CH3:18])[cH:13][cH:14]2)[CH3:19])[CH2:2][CH2:3]1.[NH2:20][c:21]1[n:22][cH:23][c:24]([Br:38])[cH:25][c:26]1-[c:27]1[cH:28][c:29]2[c:34]([cH:35][cH:36]1)[C:33](=[O:37])[NH:32][CH2:31][CH2:30]2>>[CH:1]1([CH2:4][N:5]([S:6](=[O:7])(=[O:8])[c:9]2[cH:10][n:11][c:12](-[c:24]3[cH:23][n:22][c:21]([NH2:20])[c:26](-[c:27]4[cH:28][c:29]5[c:34]([cH:35][cH:36]4)[C:33](=[O:37])[NH:32][CH2:31][CH2:30]5)[cH:25]3)[cH:13][cH:14]2)[CH3:19])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 682933526-(2-amino-5-bromopyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 70655068N-(cyclopropylmethyl)-N-methyl-6-(trimethylstannyl)pyridine-3-sulfonamide

Product 1

HCID 706549646'-amino-N-(cyclopropylmethyl)-N-methyl-5'-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-[2,3'-bipyridine]-5-sulfonamide

Sources & evidence

ORD record
ord-9508ebd8c92f4a01b83c549a91943f5f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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