HCID 19772188, compound → HCID 19772209, compound

Participants

Reaction Steps

To 1.6 g of 2-[(E)-2-(3-nitrophenyl)ethenyl]-6-[4-(4-methylphenyl)butoxy]methylpyridine was added 10 ml of methanol and then added 3 g of stannous chloride dihydride in 10 ml of methanol, and the mixture was stirred under reflux for 3.5 hours. After completion of the reaction, the solvent was distilled off and the residue was made alkaline with an aqueous sodium hydroxide solution. To the solution was added ethyl acetate and the mixture was filtered by sellaite. The organic layer was separated, washed with water, and dried over anhydrous magnesium sulfate and then the solvent was distilled off to give 1.6 g of a crude oily substance. The crude oily substance was purified on chromatography by passing chloroform and then a mixture of chloroform and ethanol(50:1) to give 1.25 g of 2-[(E)-2-(3-aminophenyl)ethenyl]-6-[4-(4-methylphenyl) butoxy]methylpyridine as an oily substance.

Provenance & Evidence