Acetone → HCID 70231090, compound

Participants

Reaction Steps

The acid prepared in Example 31 (0.75 g, 1.7 mmol) was dissolved in methanol (25 ml) and stirred under an atmosphere of hydrogen for 1 h at room temperature in the presence of 10% palladium on carbon catalyst (35% aqueous paste) and then filtered. The filtrate was evaporated to dryness leaving a residue which was treated with a mixture of ethyl acetate and acetone and filtered to give a solid which was recrystallised from toluene to give 0.20 g (26%) of the title compound as a solid. TLC: rf=0.39 (SiO2 ; methanol/dichloromethane=1 1).

Provenance & Evidence