L-Cysteic acid → Doxorubicin

Participants

Reaction Steps

50 ml doxorubicin hydrochloride solution (8.6 mg/ml) was added drop-wise under stirring to 200 ml of a solution containing sodium salt of methyl ester of N-all-trans-retinoyl cysteic acid (3 mg/mL) and sodium salt of methyl ester of 13-cis-retinoyl cysteic acid (3 mg/ml) in 500 ml round-bottom flask. Stirring was continued for an additional 20 min. The doxorubicin concentration in the obtained formulation was 1.6 mg/ml. The solution obtained was filtered through 0.2 mm filter and freeze dried. The filtration did not result in reduction of doxorubicin concentration.

Provenance & Evidence