(R)-4-(3-Oxocyclopentyl)benzonitrile → 4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]amino]cyclopentyl]benzonitrile

Participants

Reaction Steps

General procedure B was followed using 4-[(1R)-3-oxocyclopentyl]benzonitrile as the ketone and (1R)-1-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride as the amine. 1H NMR (300 MHz, DMSO) δ 7.76-7.69 (m, 2H), 7.44 (d, J=8.3 Hz, 2H), 7.15 (dd, J=8.6, 1.9 Hz, 1H), 7.09 (dd, J=11.5, 8.3 Hz, 1H), 6.88 (ddd, J=8.2, 4.5, 1.9 Hz, 1H), 3.82 (s, 3H), 3.75 (d, J=6.2 Hz, 1H), 3.07-2.85 (m, 2H), 2.23-2.03 (m, 2H), 2.00-1.54 (m, 3H), 1.40-1.19 (m, 1H), 1.23 (d, J=6.6 Hz, 3H).

Provenance & Evidence