(3s)-3-[4-(Morpholine-4-carbonyl)phenyl]-cyclopentanone → [4-[(1S,3R/S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]amino]-cyclopentyl]phenyl]-morpholino-methanone

Participants

Reaction Steps

General procedure B was followed using (3S)-3-[4-(Morpholine-4-carbonyl)phenyl]-cyclopentanone (preparation 15) as the ketone and (1R)-1-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride as the amine. 1H NMR (600 MHz, DMSO) δ 7.30-7.27 (m, 2H), 7.23 (d, J=8.2 Hz, 2H), 7.16 (dd, J=8.6, 1.9 Hz, 1H), 7.10 (dd, J=11.5, 8.2 Hz, 1H), 6.89 (ddd, J=8.1, 4.4, 1.9 Hz, 1H), 3.82 (s, 3H), 3.73 (q, J=6.4 Hz, 1H), 3.57 (m, 4H), 3.32 (m, 4H), 3.27-3.19 (m, 1H), 3.06-3.00 (m, 1H), 2.11-1.90 (m, 2H), 1.78-1.72 (m, 1H), 1.65-1.57 (m, 1H), 1.53-1.41 (m, 2H), 1.24 (d, J=6.6 Hz, 3H).

Provenance & Evidence