N-(3-amino-3-oxo-propyl)-4-[(1S)-3-oxocyclopentyl]benzamide → N-(3-amino-3-oxo-propyl)-4-[(1S,3R/S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]amino]cyclopentyl]benzamide

Participants

Reaction Steps

General procedure B was followed using N-(3-amino-3-oxo-propyl)-4-[(1S)-3-oxocyclopentyl]benzamide as the ketone and (1R)-1-(4-fluoro-3-methoxyphenyl)-ethylamine hydrochloride as the amine. 1H NMR (600 MHz, DMSO) δ 8.39 (t, J=5.6 Hz, 1H), 7.74 (d, J=8.3 Hz, 2H), 7.37-7.31 (m, 3H), 7.16 (dd, J=8.6, 1.8 Hz, 1H), 7.10 (dd, J=11.5, 8.2 Hz, 1H), 6.91-6.87 (m, 1H), 6.82 (br s, 1H), 3.83 (s, 3H), 3.77-3.71 (m, 1H), 3.46-3.37 (m, 2H), 2.99-2.87 (m, 2H), 2.34 (t, J=7.3 Hz, 2H), 2.26-2.19 (m, 1H), 1.96-1.85 (m, 1H), 1.78-1.58 (m, 2H), 1.53-1.34 (m, 2H), 1.23 (d, J=6.6 Hz, 3H).

Provenance & Evidence