Hydrogen chloride-ethyl acetate → HCID 66786277, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carboxylate prepared in (4) in ethyl acetate (30 mL) was added 4 N HCl/ethyl acetate (30 mL) at 0° C. The reaction mixture was stirred at 0° C. for 10 min and then at RT for 30 min. The reaction mixture was stirred in an ice-bath. The precipitated solid was collected on a filter and dried to give the title compound (2.61 g, 54%).

Provenance & Evidence