Water → HCID 66786530, compound

Participants

Reaction Steps

To a solution of (R)-(−)-2,2-dimethyl-1,3-dioxolan-4-methanol (0.42 mL) in DMF (10 mL) was added NaH (0.14 g). The mixture was stirred at RT for 1 hr. To the mixture was added 2-{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-ylmethyl methanesulfonate (0.80 g) prepared in (7). The reaction mixture was stirred for at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water, reduced pressure to give the crude title compound.

Provenance & Evidence