Hydrochloric Acid → HCID 49806253, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of {{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)pyridin-2-yl]-methanone prepared in (1) (0.27 g) in THF (4.0 mL) was added 1 N hydrochloric acid (2.0 mL). The reaction mixture was stirred at 60° C. for 2 hr. To the reaction mixture was added aqueous 1 N NaOH (2.0 mL) and the mixture was extracted with ethyl acetate. The solvent was removed under reduced pressure. A mixed solvent of hexane/ethyl acetate (1/1) was added to the residue. The precipitated solid was collected on a filter and dried to give the title compound (0.23 g, 93%).

Provenance & Evidence