Methanesulfonic Acid → HCID 86649374, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidine-1-carboxylate (32.4 g) prepared in (2) in ethanol (160 mL) was added methanesulfonic acid (6.3 mL). The reaction mixture was stirred at 80° C. for 3 hr. Ethyl acetate (320 mL) was added to the reaction mixture. The precipitated solid was collected on a filter and dried to give the title compound (24.3 g, 77%).

Provenance & Evidence