Piperazin-2-one → HCID 49805872, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(2-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}-pyridin-4-yloxy)ethyl methanesulfonate (0.4 g) prepared in Example 6 (1) in 1-propanol (5.0 mL) was added 2-piperazinone (0.22 g). The reaction mixture was stirred at 100° C. for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (Developing solvent: chloroform/methanol=8/1 to 7/1) to give the title compound (0.3 g, 76%).

Provenance & Evidence