Water → HCID 49806124, compound

Participants

Reaction Steps

To a mixed solution of {3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-[4-((R)-1-oxiranylmethoxy)-pyridin-2-yl]-methanone (0.45 g) prepared in (1) in acetonitrile (4.0 mL)/water (1.0 mL) was added 1-methylpiperazine (1.0 mL). The reaction mixture was stirred at RT for 12 hr. The reaction mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (Developing solvent: chloroform/methanol=9/1) to give the title compound (0.43 g, 80%).

Provenance & Evidence