HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyltributylstannane → HCID 59633949, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyltributylstannane | HCID 90628 | — |
| Reactant | 4-Chloropyridine-2-carboxylic acid ethyl ester | HCID 13015359 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59633949 | HCID 59633949 | 73% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a solution of ethyl 4-chloropyridin-2-carboxylate (0.37 g) and allyltributyltin (IV) (0.86 mL) in toluene (5.0 mL) was added tetrakis(triphenylphosphine)palladium (0) (0.12 g). The reaction mixture was stirred under nitrogen atmosphere at 120° C. for 12 hr. The solvent of the reaction mixture was removed under reduced pressure. The residue was purified by silica gel chromatography (Developing solvent: hexane/ethyl acetate=3/2) to give the title compound (0.28 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765739B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-9aeda1891f754190a23b6ed7b3aba932 |
| Source note | uspto-grants-2014_07 |