Pyridine → HCID 67995664, compound

Participants

Reaction Steps

Methyl chloroformate (0.20 mL) is added dropwise to a solution of 7-{2-[(S)-1-(4-bromo-phenyl)-ethylamino]-ethyl}-1,4-dioxa-spiro[4.5]decan-7-ol (0.50 g), triethylamine (0.4 mL), and pyridine (0.2 mL) in dichloromethane (10 mL) chilled in an ice bath. The solution is warmed to room temperature and stirred at this temperature overnight. Water is then added and the resulting mixture is extracted with dichloromethane. The combined extracts are washed with water (3×), dried (MgSO4), and concentrated. The residue is purified by HPLC on reversed phase (methanol/water) to give the title compound. Yield: 0.30 g (50% of theory); Mass spectrum (ESI+): m/z=442/444 (Br) [M+H]+.

Provenance & Evidence