HCID 67995940, compound → HCID 67995749, compound

Participants

Reaction Conditions

Reaction Steps

3-(9-Allyl-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-3-cyano-propionic acid ethyl ester (4.21 g) is dissolved in a solution of KOH (16.5 g) in ethylene glycol (110 mL) and the resulting mixture is heated to 190° C. and stirred at this temperature for 3 h. After cooling to room temperature, the solution is diluted with water and neutralized with acetic acid. The resulting solution is extracted several times with ethyl acetate. The extracts are combined and the solvent is evaporated. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 1:0→1:1) to give the title compound. Yield: 3.54 g (quantitative); Mass spectrum (ESI+): m/z=283 [M+H]+.

Provenance & Evidence