(S)-1-(4-tert-butylphenyl)ethanamine → HCID 67996114, compound

HRID 1615140Notes

Reaction equation

HRID 1615140 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[C:18]([C:22]1[CH:27]=[CH:26][C:25]([C@@H:28]([NH2:30])[CH3:29])=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([C:22]1[CH:23]=[CH:24][C:25]([C@@H:28]([NH:30][CH2:16][CH2:15][C:2]2([OH:1])[CH2:14][CH2:13][C:5]3([O:6][CH2:7][C:8]([CH3:12])([CH3:11])[CH2:9][O:10]3)[CH2:4][CH2:3]2)[CH3:29])=[CH:26][CH:27]=1)([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 7026229(S)-1-(4-tert-butylphenyl)ethanamineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996114HCID 67996114, compoundYield 55%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(4-tert-butyl-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 55% of theory; LC (method 5): tR=1.22 min; Mass spectrum (ESI+): m/z=404 [M+H]+.

Sources & evidence

ORD record
ord-8ac02f016497441197a245e99552c7c6
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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