(1S)-1-(Naphthalen-2-yl)ethan-1-amine → HCID 67996101, compound

HRID 1615147Notes

Reaction equation

HRID 1615147 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[C@@H:28]([NH2:30])[CH3:29]>>[CH3:12][C:8]1([CH3:11])[CH2:9][O:10][C:5]2([CH2:13][CH2:14][C:2]([CH2:15][CH2:16][NH:30][C@H:28]([C:19]3[CH:20]=[CH:21][C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:18]=3)[CH3:29])([OH:1])[CH2:3][CH2:4]2)[O:6][CH2:7]1

Participants

3

Reactant 2

HCID 1201503(1S)-1-(Naphthalen-2-yl)ethan-1-amineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996101HCID 67996101, compoundYield 78%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-naphthalen-2-yl-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 78% of theory; LC (method 6): tR=1.27 min; Mass spectrum (ESI+): m/z=398 [M+H]+.

Sources & evidence

ORD record
ord-7d185fa6f67d4b85bf97e06612d35d57
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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