1-Aminoindane, (S)- → HCID 67996264, compound

HRID 1615149Notes

Reaction equation

HRID 1615149 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[C@@H:18]1([NH2:27])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19]1>>[C@@H:18]1([NH:27][CH2:16][CH2:15][C:2]2([OH:1])[CH2:3][CH2:4][C:5]3([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]3)[CH2:13][CH2:14]2)[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 70000841-Aminoindane, (S)-HCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996264HCID 67996264, compoundYield 26%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-indan-1-ylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 26% of theory; LC (method 6): tR=1.11 min; Mass spectrum (ESI+): m/z=360 [M+H]+.

Sources & evidence

ORD record
ord-af5e8e32a116431d97f8416ed54bc79b
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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