HCID 70497275, compound → HCID 67995838, compound

Participants

Reaction Steps

The title compound is prepared from 12,12-dimethyl-3-{(S)-1-[4-(1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-phenyl]-ethyl}-1,10,14-trioxa-3-aza-dispiro[5.2.5.2]hexadecan-2-one following a procedure analogous to that described in Step 10 of Intermediate 2. Yield: 48% of theory; Mass spectrum (ESI+): m/z=395 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 1.55 (d, J=7.1 Hz, 3H), 1.85-2.05 (m, 5H), 2.08-2.27 (m, 3H), 2.44-2.56 (m, 2H) superimposed by DMSO-d5, 2.81-2.89 (m, 1H), ca. 3.25-3.33 (m, 1H) superimposed by H2O, 3.45 (s, 3H), 5.54 (q, J=7.1 Hz, 1H), 6.57 (dd, J=7.1, 2.0 Hz, 1H), 6.68 (d, J=2.0 Hz, 1H), 7.42 (dm, J=8.2 Hz, 2H), 7.72 (dm, J=8.2 Hz, 2H), 7.76 (d, J=7.1 Hz, 1H).

Provenance & Evidence