HCID 67996124, compound → HCID 67996267, compound

Participants

Reaction Steps

The title compound is prepared from 5-{4-[(S)-1-(12,12-dimethyl-2-oxo-1,10,14-trioxa-3-aza-dispiro[5.2.5.2]hexadec-3-yl)-ethyl]-phenyl}-pyridine-2-carboxylic acid dimethylamide following a procedure analogous to that described in Step 10 of Intermediate 2. Yield: 54% of theory; Mass spectrum (ESI+): m/z=436 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 1.57 (d, J=7.1 Hz, 3H), 1.85-2.05 (m, 5H), 2.09-2.28 (m, 3H), 2.45-2.57 (m, 2H) superimposed by DMSO-d5, 2.83-2.91 (m, 1H), 3.01 (s, 3H), 3.03 (s, 3H), ca. 3.27-3.35 (m, 1H) superimposed by H2O, 5.56 (q, J=7.1 Hz, 1H), 7.47 (dm, J=8.2 Hz, 2H), 7.65 (dm, J=8.2 Hz, 1H), 7.79 (dm, J=8.2 Hz, 2H), 8.20 (dd, J=8.2, 2.3 Hz, 1H), 8.91 (d, J=2.3 Hz, 1H).

Provenance & Evidence