Triphosgene → HCID 67995835, compound

Participants

Reaction Steps

The title compound is prepared from 9-{2-[(S)-1-(4-methoxy-phenyl)-propylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol and triphosgene following a procedure analogous to that described in Step 4 of Intermediate 2; the crude product, a mixture of the title compound and 3-[(S)-1-(4-methoxy-phenyl)-propyl]-12,12-dimethyl-1,10,14-trioxa-3-aza-dispiro[5.2.5.2]hexadecan-2-one, obtained after that is treated as described in Step 10 of Intermediate 2 to convert the intermediate to the title compound as well. Yield: 62% of theory; LC (method 6): tR=1.33 min; Mass spectrum (ESI+): m/z=332 [M+H]+.

Provenance & Evidence