Triphosgene → 3-[(S)-1-o-Tolyl-ethyl]-1-oxa-3-aza-spiro[5.5]undecane-2,9-dione

Participants

Reaction Steps

The title compound is prepared from 3,3-dimethyl-9-{2-[(S)-1-o-tolyl-ethylamino]-ethyl}-1,5-dioxa-spiro[5.5]undecan-9-ol and triphosgene following a procedure analogous to that described in Step 4 of Intermediate 2; the crude product, a mixture of the title compound and 12,12-di methyl-3-[(S)-1-o-tolyl-ethyl]-1,10,14-trioxa-3-aza-dispiro[5.2.5.2]hexadecan-2-one, obtained thereafter is treated as described in Step 10 of Intermediate 2 to convert the intermediate to the title compound as well. Yield: 17% of theory; LC (method 8): tR=1.23 min; Mass spectrum (ESI+): m/z=302 [M+H]+.

Provenance & Evidence