Trifluoroacetic acid → HCID 178525663, compound

Participants

Reaction Steps

To (E)-tert-butyl 3-((1H-indazol-6-yl)methylene)-2-oxoindolin-5-ylcarbamate (15 mg, 0.040 mmol) in CH2Cl2 (2 mL) was added TFA (0.1 mL). After 1.5 hrs the solvent was removed and the product precipitated with ether and filtered washing with ether to give 9 mg, 56% of the title compound as a brown solid. 1H NMR (400 MHz, d6-DMSO) δ 13.41 (s, 1H), 10.79 (s, 1H), 9.25-8.90 (bs, 3H), 9.01 (s, 1H), 8.14 (s, 1H), 8.00-7.96 (m, 2H), 7.82 (d, J=8.5 Hz, 1H), 7.56 (s, 1H), 7.09-7.07 (m, 1H), 6.86 (d, J=8.1 Hz, 1H); MS ESI 277.0 [M]+, calcd for [C16H13N4O]+ 277.11.

Provenance & Evidence