HCID 22571140, compound → HCID 178504980, compound

HRID 1615236Notes

Reaction equation

HRID 1615236 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=2)[NH:3]1.[NH:16]1[C:20]2[CH:21]=[CH:22][C:23]([CH:25]=O)=[CH:24][C:19]=2[N:18]=[N:17]1>>[NH:16]1[C:20]2[CH:21]=[CH:22][C:23](/[CH:25]=[C:10]3/[C:2](=[O:1])[NH:3][C:4]4[C:9]/3=[CH:8][C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:6][CH:5]=4)=[CH:24][C:19]=2[N:18]=[N:17]1

Participants

3

Reactant 2

HCID 22571140HCID 22571140, compoundHCID 178519382HCID 178519382, compound

Product 1

HCID 178504980HCID 178504980, compound

Procedure

According to the method of Example A20, except substituting N-(2-oxoindolin-5-yl)methanesulfonamide (12 mg, 0.053 mmol) and 1H-benzo[d][1,2,3]triazole-5-carbaldehyde (9 mg, 0.058 mmol), the title compound was obtained as an orange solid (8 mg, 42%). 1H NMR (400 MHz, CDCl3) δ 8.22 (s, 1H), 8.00 (d, J=8.6 Hz, 1H), 7.93 (s, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.61 (s, 1H), 7.14 (d, J=8.4 Hz, 1H), 6.91 (d, J=8.3 Hz, 1H), 2.86 (s, 3H); MS ESI 356.0 [M+H]+, calcd for [C16H13N5O3S+H]+ 356.1.

Sources & evidence

ORD record
ord-29d5051d10444883a5d2e97a11d00dcf
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

Loading…