Hydrazine hydrate (1:1) → HCID 68756246, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(1,3-dioxolan-2-yl)-2-fluorobenzonitrile (567 mg, 3 mmol) in n-butanol (5 mL) was added hydrazine hydrate (1.47 mL, 30 mmol). The solution was heated to 110° C. for 2 h and cooled to room temperature. The solution was stirred overnight and the resulting precipitate was collected to give the title compound as a white solid (220 mg, 36%). 1H NMR (400 MHz, DMSO-d6) δ 11.44 (s, 1H), 7.78 (s, 1H), 7.28-7.26 (m, 1H), 7.21-7.19 (m, 1H), 5.72 (s, 1H), 5.37 (bs), 4.08-4.02 (m, 2H), 3.98-3.92 (m, 2H); MS ESI 206.0 [M+H]+, calcd for [C10H11N3O2+H]+ 206.1.

Provenance & Evidence