p-Toluenesulfonic acid → HCID 82415458, compound

Participants

Reaction Steps

To a solution of 5-(1,3-dioxolan-2-yl)-1H-indazol-3-amine (75 mg, 0.36 mmol) in THF (5 mL) and H2O (0.5 mL) was added p-toluene sulfonic acid (25 mg) and the reaction was stirred overnight at room temperature. Ethyl acetate (75 mL) was added and the solution was washed with sat. sodium bicarbonate (5 mL), brine (2×5 mL), dried over MgSO4 and concentrated to give the title compound as an orange solid (52 mg, 89%). 1H NMR (400 MHz, CD3OD) δ 9.68 (s, 1H), 8.94 (s, 1H), 8.18 (d, 1H, J=7.6 Hz), 7.68 (d, 1H, J=8.4 Hz).

Provenance & Evidence