Acetic Anhydride → HCID 68733405, compound

HRID 1615255Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[O:11]=[C:8]1[CH2:7][C:6]2[C:10](=[C:2]([NH:1][C:12](=[O:14])[CH3:13])[CH:3]=[CH:4][CH:5]=2)[NH:9]1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 64233127-aminoindolin-2-one

Product 1

HCID 68733405HCID 68733405, compoundYield 80%

Procedure

According to the method described in example A48a, 7-aminoindolin-2-one (80 mg, 0.54) was reacted with acetic anhydride (66 mg, 0.65 mmol) to give the title compound as a white solid (82 mg, 80%). 1H NMR (400 MHz, CD3OD) δ 7.13 (d, 2H, J=8 Hz), 6.99 (t, 1H, J=8 Hz), 3.57 (s, 2H), 2.16 (s, 3H). MS ESI [M+H]+, calcd for [C10H10N2O2+H]+ 191.08; found m/z 191.0.

Sources & evidence

ORD record: ord-3f97c849a503405d9b370ce8feceb24a
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765748B2

Reaction notes

Loading…