Tetrabutylammonium Fluoride → HCID 86651958, compound

Participants

Reaction Steps

A solution of (E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (63 mg, 0.166 mmol) in THF (2.0 mL) was treated with TBAF (0.83 mL of a 1M solution in THF) and refluxed overnight. The solvent was removed and the residue re-dissolved into EtOAc. The organics were washed with water (2×), brine (2×) and then dried (MgSO4). The solvent was removed and the residue purified by column chromatography (silica gel, 98:2 CH2Cl2/MeOH) to give the title compound (27 mg, 66%) which was used without further purification. MS ESI 249.0 [M+H]+, calcd for [C16H12N2O+H]+ 249.10.

Provenance & Evidence