Piperidine → HCID 68758106, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-(2-(pyridin-4-yl)ethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (54 mg, 0.142 mmol), oxindole (19 mg, 0.142 mmol) in MeOH (2.0 mL) was treated with piperidine (1.5 uL, 0.0142 mmol) and the reaction heated to 60° C. and stirred for 4 hours at which time the solvent was removed and the residue purified by column chromatography (silica gel, 96:4 CH2Cl2/MeOH) to give the title compound (57 mg, 80%) as a yellow film. MS ESI 497.2 [M+H]+, calcd for [C29H32N4O2Si+H]+ 497.24.

Provenance & Evidence