反应详情

The title compound (7 mg, 21%) was synthesized as an orange solid according to the method described for Example A67 using oxindole (13.3 mg, 0.1 mmol) and (E)-3-(6-formyl-1H-indazol-3-yl)acrylic acid (21.6 mg, 0.1 mmol). NMR (400 MHz, DMSO-d6) δ 13.80 (br. s, 1H, NH), 10.64 (s, 1H, CO2H), 8.20 (d, J=8.4 Hz, 1H), 7.94 (s, 1H), 7.85 (d, J=16.4 Hz, 1H), 7.78 (s, 1H), 7.58-7.53 (m, 2H), 7.24 (t, J=7.6 Hz, 1H), 6.88 (d, J=8.0 Hz, 1H), 6.84 (t, J=7.8 Hz, 1H), 6.75 (d, J=16.0 Hz, 1H); MS ESI 332.1 [M+H]+, calcd for [C19H13N3O3+H]+ 322.1.