1H-Indazol-6-amine → HCID 135912038, compound

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Reaction Steps

The title compound (76 mg, 54%) was synthesized as a dark red solid according to the method described for Example A74 using 5-fluoroisatin (82.5 mg, 0.5 mmol) and 6-aminoindazole (66.5 mg, 0.5 mmol). NMR analysis indicated a 79:21 mixture of E/Z isomers. 1H NMR (400 MHz, DMSO-d6) δ 13.08 (s, 1H, NH), 11.03 (s, 1H, NH), 8.11 (s, 1H), 7.87 (d, J=8.4 Hz, 1H), 7.22 (dt, J=9.2 Hz, 2.8 Hz, 1H), 6.90 (dd, J=8.4 Hz, 4.4 Hz, 1H), 6.82-6.77 (m, 1H), 5.98 (dd, J=8.0 Hz, 2.0 Hz, 1H); MS ESI 281.0 [M+H]+, calcd for [C15H9FN4O+H]+ 281.1.

Provenance & Evidence