5-Chlorooxindole → HCID 178517159, compound

Participants

Reaction Steps

According to the procedure for the synthesis of (E)-3-((3-((E)-2-(pyridin-4-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one (Example A57), except substituting 5-chlorooxindole (14 mg, 0.08 mmol), the title compound was prepared as an orange solid (13.5 mg, 42%). 1H NMR (400 MHz, d6-DMSO) δ 13.63 (br s, 1H), 10.78 (br. s, 1H), 8.56 (d, J=4.0 Hz, 2H), 8.40 (d, J=10.0 Hz, 1H), 7.91 (s, 1H), 7.89 (d, J=13.2 Hz, 2H), 7.72 (d, J=3.5 Hz, 2H), 7.57 (d, J=12.0 Hz, 1H), 7.52 (d, J=12.0 Hz, 2H), 7.30 (d, J=10.0 Hz, 1H), 6.90 (d, J=11.5 Hz, 1H); MS ESI 399.2 [M+H]+, calcd for [C23H15ClN4O+H]+ 399.09.

Provenance & Evidence