5-Methoxyoxindole → HCID 178487102, compound

Participants

Reaction Steps

According to procedure for the synthesis of (E)-3-((3-((E)-2-(pyridin-4-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one, except substituting 5-methoxyoxindole (11 mg, 0.068 mmol) to give the title compound as an orange solid (13.6 mg, 51%). 1H NMR (400 MHz, d6-DMSO) δ 13.58 (br s, 1H), 10.45 (br s, 1H), 8.57 (d, J=6.0 Hz, 2H), 8.37 (d, J=8.5 Hz, 1H), 7.93 (s, 1H), 7.87 (d, J=16.6 Hz, 1H), 7.79 (s, 1H), 7.71 (d, J=6.0 Hz, 2H), 7.57 (d, J=2.3 Hz, 1H), 7.54 (d, J=6.3 Hz, 1H), 7.18 (d, J=10.0 Hz, 1H), 6.86 (dd, J=8.8, 2.5 Hz, 1H) 6.80 (d, J=8.3 Hz, 1H), 3.6 (s, 3H); MS ESI 395.2 [M+H]+, calcd for [C24H18N4O2+H]+ 395.14.

Provenance & Evidence