m-Chloroperbenzoic acid → HCID 178487093, compound

Participants

Reaction Steps

A round bottom flask was charged with (E)-5-methoxy-3-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one (25 mg, 0.063 mmol), mCPBA (13 mg, 0.076 mmol), and dichloromethane (4 mL). The reaction was stirred at rt for 24 hrs. Solvent was removed in vacuo and the residue was loaded onto a silica gel column. Elution with 90:10 CH2Cl2/MeOH gave 9 mg (35%) of the title compound as an orange solid. 1H NMR (400 MHz, CD3OD) δ 8.41 (d, J=6.0 Hz, 1H), 8.31 (d, J=8.5 Hz, 1H), 8.19 (d, J=16.3 Hz, 1H), 8.14 (d, J=8.0 Hz, 1H), 8.04 (d, J=17.1 Hz, 1H), 7.91 (d, J=16.1 Hz, 2H), 7.67-7.60 (m, 2H), 7.47-7.43 (m, 1H), 7.25 (s, 1H), 6.85 (s, 2H), 3.64 (s, 3H); MS ESI 411.2 [M+H]+, calcd for [C24H18N4O3+H]+ 411.14.

Provenance & Evidence