HCID 86651964, compound → HCID 178517045, compound

HRID 1615301Notes

Reaction equation

HRID 1615301 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7](/[CH:10]=[C:11]3/[C:12](=[O:20])[NH:13][C:14]4[C:19]/3=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:8]=2)[CH:3]=[N:2]1.[S:21]1[CH:25]=[CH:24][CH:23]=[C:22]1C1C2C(=CC(C=O)=CC=2)NN=1>>[S:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:3]1[C:4]2[C:9](=[CH:8][C:7](/[CH:10]=[C:11]3/[C:12](=[O:20])[NH:13][C:14]4[C:19]/3=[CH:18][CH:17]=[CH:16][CH:15]=4)=[CH:6][CH:5]=2)[NH:1][N:2]=1

Participants

3

Reactant 2

HCID 86651964HCID 86651964, compoundHCID 178517060(3E)-3-(1H-indazol-6-ylmethylidene)-1H-indol-2-one

Product 1

HCID 178517045HCID 178517045, compound

Procedure

According to the procedure for the synthesis of (E)-3-((1H-indazol-6-yl)methylene)indolin-2-one, except substituting 3-(thiophen-2-yl)-1H-indazole-6-carbaldehyde (29 m 0.13 mmol), the title compound was prepared as a yellow solid (19.7 mg, 45%). 1H NMR (400 MHz, d6-DMSO) δ 10.64 (br s, 1H), 8.22 (d, J=8.5 Hz, 1H), 7.92 (s, 1H), 7.79 (s, 2H), 7.61 (d, J=7.5 Hz, 1H), 7.59 (d, J=5.0 Hz, 1H), 7.53 (d, J=8.0 Hz, 1H), 7.26-7.20 (m, 2H), 6.89 (d, J=7.5 Hz, 1H), 6.85 (t, J=7.5 Hz, 1H); MS ESI 344.1 [M+H]+, calcd for [C20H13N3OS+H]+ 344.08.

Sources & evidence

ORD record
ord-ee813d3784e84e798a60cde2d9494d2b
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

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