HCID 86651967, compound → HCID 178517046, compound

Participants

Reaction Steps

According to the procedure for the synthesis of (E)-3-((1H-indazol-6-yl)methylene)-indolin-2-one, except substituting 3-(quinolin-3-yl)-1H-indazole-6-carbaldehyde (8 mg, 0.03 mol), the title compound was obtained as a yellow solid (4.3 mg, 38%). A mixture of (E)- and (Z)-isomers (94:6 by NMR) was obtained. 1H NMR (400 MHz, d6-DMSO) δ 13.75 (br s, 1H), 10.66 (br. s, 1H), 9.61 (d, J=2.0 Hz, 1H), 9.04 (d, J=2.3 Hz, 1H), 8.47 (d, J=8.8 Hz, 1H), 8.22 (d, J=7.8 Hz, 1H), 8.08 (d, J=8.0 Hz, 1H), 8.01 (s, 1H), 7.83 (s, 1H), 7.80 (td, J=6.8, 1.3 Hz, 1H), 7.68 (t, J=7.8, 1H), 7.64 (d, J=7.8 Hz, 1H), 7.61 (d, J=7.8 Hz, 1H), 7.25 (t, J=7.8 Hz, 1H), 6.90 (d, J=8.3 Hz, 1H), 6.86 (t, J=7.8 Hz, 1H); MS ESI 389.1 [M+H]+, calcd for [C25H16N4O+H]+ 389.13.

Provenance & Evidence