1,3-Dihydro-2H-pyrrolo(2,3-b)pyridin-2-one → HCID 178517369, compound

Participants

Reaction Steps

The title compound (64 mg, 64%) was synthesized as orange red solid according to the method described for Example A11B from 1H-pyrrolo[2,3-b]pyridin-2(3H)-one (26.8 mg, 0.2 mmol) and E)-3-(2-(pyridin-4-yl)vinyl)-1H-indazole-6-carbaldehyde (49.8 mg, 0.2 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.60 (s, 1H, NH), 11.28 (s, 1H, NH), 8.57 (d, J=5.6 Hz, 2H), 8.39 (d, J=8.4 Hz, 1H), 8.12 (d, J=4.8 Hz, 1H), 7.95 (s, 2H), 7.90 (d, J=6.4 Hz, 1H, partially overlapping with the peak at 7.87 ppm), 7.87 (d, J=16.4 Hz, 1H, partially overlapping with the peak at 7.90 ppm), 7.71 (d, J=5.6 Hz, 2H), 7.57 (d, J=8.0 Hz, 1H, partially overlapping with the peak at 7.56 ppm), 7.56 (d, J=16.4 Hz, 1H, partially overlapping with the peak at 7.57 ppm), 6.91 (dd, J=7.6 Hz, 5.2 Hz, 1H); MS ESI 366.1 [M+H]+, calcd for [C22H15N5O+H]+ 366.1.

Provenance & Evidence