5-Methoxyoxindole → HCID 178471184, compound

Participants

Reaction Steps

The title compound (60 mg, 77%) was synthesized as an orange red solid according to the method described for Example A67 (oil temp 75° C., reflux 2 h) using 5-methoxyoxindole (26.8 mg, 0.2 mmol) and (E)-ethyl 3-(6-formyl-1H-indazol-3-yl)acrylate (48.8 mg, 0.2 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.80 (brs, 1H, NH), 10.44 (s, 1H, NH), 8.26 (d, J=8.4 Hz, 1H), 7.96 (s, 1H), 7.92 (d, J=16.4 Hz, 1H), 7.77 (s, 1H), 7.56 (d, J=8.4 Hz, 1H), 7.14 (d, 1H), 6.90-6.80 (m, 3H), 4.23 (q, J=7.2 Hz, 2H), 3.58 (s, 3H), 2.29 (t, J=7.2 Hz, 3H); MS ESI 390.3 [M+H]+, calcd for [C22H19N3O4+H]+ 390.1.

Provenance & Evidence