4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine → 3-(6-Morpholinopyridin-3-yl)-1h-indazole-6-carbaldehyde

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Reaction Steps

According to procedure for the synthesis of 3-(pyridin-3-yl)-1H-indazole-6-carbaldehyde, except substituting 2-(4-morpholino)pyridine-5-boronic acid pinacol ester (64 mg, 0.22 mmol), the title compound was prepared as a yellow powder (35 mg, 62%). 1H NMR (400 MHz, d6-DMSO) δ ppm 13.71 (br s, 1H), 10.14 (s, 1H), 8.77 (d, J=1.9 Hz, 1H), 8.02-8.18 (m, 2H), 8.15 (dd, J=8.9 Hz, 2.5, 1H), 7.64 (d, J=8.6 Hz, 1H), 7.00 (d, J=8.8 Hz, 1H), 3.73 (t, J=4.5 Hz, 4H), 3.53 (t, J=5.1 Hz, 4H); MS ESI 309.1 (100) [M+H]+, calcd for [C17H16N4O2+H]+ 309.13.

Provenance & Evidence