HCID 178487093, compound → HCID 178487103, compound

Participants

Reaction Steps

According to the procedure for the synthesis of 2-((E)-2-(6-((E)-(5-methoxy-2-oxoindolin-3-ylidene)methyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide (Example A88), except substituting (E)-5-methoxy-3-((3-((E)-2-(pyridin-4-yl)vinyl)-1H-indazol-6-yl)methyl-ene)indolin-2-one (8.1 mg, 0.021 mmol), the title compound was prepared as an orange solid (1.3 mg, 15%.). 1H NMR (400 MHz, DMSO-d6) δ 13.55 (br. s, 1H), 10.45 (s, 1H), 8.35 (d, J=8.6 Hz, 1H), 8.20 (d, J=6.8 Hz, 2H), 7.93 (s, 1H), 7.79-7.72 (m, 4H), 7.55 (d, J=14.3 Hz, 1H), 7.54 (d, J=8.9 Hz, 1H), 7.17 (d, J=2.7 Hz, 1H), 6.86 (dd, J=8.5, 2.7 Hz, 1H), 6.80 (d, J=8.5 Hz, 1H), 3.60 (s, 3H); MS ESI 411.2 [M+H]+, calcd for [C24H18N4O3+H]+ 411.14.

Provenance & Evidence