5-Methoxyoxindole → HCID 178487104, compound

Participants

Reaction Steps

The synthetic method followed that described in Example A66 starting from 5-methoxyoxindole (10 mg, 0.0583 mmol) and (E)-3-(3-(4-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (25 mg, 0.0.0583 mmol) to give 2.5 mg of the title compound as an 85:15 mixture of (E)/(Z) isomers. 1H NMR (400 MHz, CD3OD) 8.95, 7.80 (s, 1H), 8.21-8.16 (m, 1H), 7.97-7.87 (m, 2H), 7.59 (d, J=7.52 Hz, 1H), 7.45 (d, J=15.7 Hz, 1H), 7.32, 7.22 (s, 1H), 6.85 (s, 2H), 3.84, 3.63 (s, 3H), 3.90-3.75 (m, 4H), 2.62-2.48 (br. s, 4H), 2.34 (s, 3H); MS ESI 444.2 [M+H]+, calcd for [C25H25N5O3+H]+ 444.20.

Provenance & Evidence