HCID 68733405, compound → HCID 178474080, compound

HRID 1615336Notes

Reaction equation

HRID 1615336 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[C:5]([NH:11][C:12](=[O:14])[CH3:13])[CH:6]=[CH:7][CH:8]=2)[NH:3]1.[N:15]1[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]2[C:31]3[C:26](=[CH:27][C:28]([CH:32]=O)=[CH:29][CH:30]=3)[N:25](COCC[Si](C)(C)C)[N:24]=2)=[CH:17][CH:16]=1>>[O:1]=[C:2]1[NH:3][C:4]2[C:9](/[C:10]/1=[CH:32]\[C:28]1[CH:27]=[C:26]3[C:31]([C:23](/[CH:22]=[CH:21]/[C:18]4[CH:17]=[CH:16][N:15]=[CH:20][CH:19]=4)=[N:24][NH:25]3)=[CH:30][CH:29]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[NH:11][C:12](=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 68733405HCID 68733405, compoundHCID 86651957HCID 86651957, compound

Product 1

HCID 178474080HCID 178474080, compoundYield 94.9%

Procedure

According to the method of A57B, N-(2-oxoindolin-7-yl)acetamide (30 mg, 0.16 mmol) was reacted with (E)-3-(2-(pyridin-4-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (60 mg, 0.16 mmol) to give the title compound as an orange solid (64 mg, 72%). MS ESI 552.3 [M+H]+, calcd for [C31H33N5O3Si+H]+ 552.2.

Sources & evidence

ORD record
ord-0b0aed75539b44698fb78bec153c04be
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

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