Hydrochloric Acid → HCID 178474080, compound

Participants

Reaction Steps

According to the method of A57C, N-((E)-2-oxo-3-((3-((E)-2-(pyridin-4-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)methylene)indolin-7-yl)acetamide (64 mg, 0.11 mmol) was treated with boron trifluoride etherate, followed by 2 N HCl to give the title compound as an orange solid (33 mg, 71%). 1H NMR (400 MHz, d6-DMSO) δ 10.33 (s, 1H), 9.42 (s, 1H), 8.85 (d, J=6.2 Hz, 2H), 8.46-8.30 (m, 4H), 7.98 (s, 1H), 7.87-7.78 (m, 2H), 7.80 (s, 1H), 7.63 (d, J=8.2 Hz, 1H), 7.42-7.35 (m, 2H), 6.81 (t, J=8.1 Hz, 1H), 2.05 (s, 3H); MS ESI 422.1 [M+H]+, calcd for [C25H19N5O2+H]+ 422.2.

Provenance & Evidence