4-bromo-2,3-dihydro-1H-indol-2-one → HCID 178517037, compound

Participants

Reaction Steps

The title compound was synthesized according to the method of Example A19, utilizing 4-bromoindolin-2-one (50 mg, 0.23 mmol) and 1H-indazole-6-carbaldehyde (34.5 mg, 0.23 mmol). On completion the reaction mixture was stored at rt overnight. Filtration and rinsing with xs EtOH provided the title compound as an orange solid (30 mg, 38%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13.36 (br. s., 1H), 10.91 (br. s., 1H), 8.78 (s, 1H), 8.73 (s, 1H), 8.13 (s, 1H), 7.80 (d, J=8.28 Hz, 1H), 7.65 (d, J=8.28 Hz, 1H), 7.22 (d, J=8.28 Hz, 1H), 7.16 (t, J=7.78 Hz, 1H), 6.88 (d, J=7.78 Hz, 1H); MS ESI [M+H]+ 340.1/341.9, calcd for [C16H10BrN3O+H]+ 340.0/342.0.

Provenance & Evidence