Oxindole → HCID 178497725, compound

Participants

Reaction Steps

The title compound (40 mg, 83%) was synthesized as an orange solid according to the method described for Example A67 (oil temp 75° C., reflux 150 min) using indolin-2-one (26.6 mg, 0.2 mmol) and (E)-methyl 4-(2-(6-formyl-1H-indazol-3-yl)vinyl)benzoate (61.2 mg, 0.2 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.60 (s, 1H), 10.70 (s, 1H), 9.00 (s, 1H), 8.29 (d, J=8.0 Hz, 1H), 8.08 (d, J=8.4 Hz, 1H), 8.00 (s, 1H), 7.98 (d, J=8.0 Hz, 2H), 7.88 (d, J=8.0 Hz, 2H), 7.77 (d, J=8.4 Hz, 1H, partially overlapping with the doublet at 7.74), 7.74 (d, J=17.2 Hz, 1H, partially overlapping with the doublet at 7.77), 7.63 (d, J=17.2 Hz, 1H), 7.23 (t, J=7.6 Hz, 1H), 7.01 (t, J=7.6 Hz, 1H), 6.84 (d, J=7.6 Hz, 1H), 3.86 (s, 3H); MS ESI 422.3 [M+H]+, calcd for [C26H19N3O3+H]+ 422.1.

Provenance & Evidence