Oxindole → HCID 178517050, compound

Participants

Reaction Steps

The title compound (17 mg, 21%) was synthesized as an orange solid according to the method described for Example A67 (oil temp 75° C., reflux 90 min) using indolin-2-one (26.6 mg, 0.2 mmol) and (E)-4-(2-(6-formyl-1H-indazol-3-yl)vinyl)benzoic acid (58.4 mg, 0.2 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.49 (s, 1H), 12.90 (s, br, 1H), 10.64 (s, 1H), 8.37 (d, J=8.4 Hz, 1H), 7.97 (d, J=8.4 Hz, 2H), 7.91 (s, 1H), 7.86 (d, J=8.0 Hz, 2H), 7.80 (s, 1H), 7.74 (d, J=16.8 Hz, 1H), 7.63 (d, J=15.6 Hz, 1H partially overlapping with the singlet at 7.62), 7.62 (s, 1H partially overlapping with the doublet at 7.63), 7.24 (t, J=7.4 Hz, 1H), 6.91-6.82 (m, 2H); MS ESI 408.2 [M+H]+, calcd for [C25H17N3O3+H]+ 408.1.

Provenance & Evidence