Oxindole → HCID 178517052, compound

Participants

Reaction Steps

The title compound (30 mg, 83%) was synthesized as a yellow solid according to the method described for Example A67 (oil temp 75° C., reflux 2 h) using indolin-2-one (13.3 mg, 0.1 mmol) and 3-(pyridin-3-ylethynyl)-1H-indazole-6-carbaldehyde (24.7 mg, 0.1 mmol). 1H NMR (400 MHz, DMSO-d6) δ 13.80 (s, 1H), 10.64 (s, 1H), 8.90 (s, 1H), 9.64 (d, J=4.4 Hz, 1H), 8.12 (d, J=8.0 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.96 (s, 1H), 7.80 (s, 1H), 7.60-7.50 (m, 3H), 7.24 (t, J=7.8 Hz, 1H), 6.89 (d, J=7.6 Hz, 1H) 6.84 (t, J=7.8 Hz, 1H); MS ESI 363.1 [M+H]+, calcd for [C23H14N4O+H]+ 363.1.

Provenance & Evidence